Centro cultural para la revitalización cultural en el distrito de Independencia - Huaraz 2021

El Centro cultural para la revitalización cultural tiene la finalidad de desarrollar actividades artísticas culturales creativas como un eje para el desarrollo educativo y económico en nuestra localidad. Proponemos esta alternativa de solución de acuerdo a nuestro contexto, se realizó investigaciones sobre el distrito de Independencia de Huaraz, en artes, educación y economía, posteriormente se investigó casos análogos donde las artes y la sociedad van de la mano para enfrentar la problemática que se asemejan a nuestro distrito y además sobre la globalización, el desinterés de los gobernantes de difundir la herencia milenaria como las posibles soluciones que estas proponen, además la recopilación de antecedentes indican el logro de revitalizar zonas y sub zonas marginales de ciudades de diferentes partes del mundo con inversiones públicas y privadas enfocadas a la difusión de las artes y creatividad, hoy en día son ciudades prosperas gracias a estas edificaciones debidamente equipadas. Llegando a la conclusión que el proyecto cubre las necesidades socioculturales del distrito de Independencia teniendo en cuenta factores como la expansión urbana la incorporación de entidades públicas y privadas y la gran riqueza cultural evidenciada en los restos arqueológicos de los antiguos pobladores de la región

Nota preliminar sobre la estratigrafía y el contenido en conodontos del Prídolí-Lochkoviense inferior en la unidad de els Castells (Pirineo central)

Instituto Geológico Minero de España; DGE PB95-104

Adaptive trajectory tracking control for quadrotors with disturbances by using generalized regression neural networks

In this document, the development and experimental validation of a nonlinear controller with an adaptive disturbance compensation system applied on a quadrotor are presented. The introduced scheme relies on a generalized regression neural network (GRNN). The proposed scheme has a structure consisting of an inner control loop inaccessible to the user (i.e., an embedded controller) and an outer control loop which generates commands for the inner control loop. The adaptive GRNN is applied in the outer control loop. The proposed approach lies in the aptitude of the GRNN to estimate the disturbances and unmodeled dynamic effects without requiring accurate knowledge of the quadrotor parameters. The adaptation laws are deduced from a rigorous convergence analysis ensuring asymptotic trajectory tracking. The proposed control scheme is implemented on the QBall 2 quadrotor. Comparisons with respect to a PD-based control, an adaptive model regressor-based scheme, and an adaptive neural-network controller are carried out. The experimental results validate the functionality of the novel control scheme and show a performance improvement since smaller tracking error values are produced.Fil: Lopez Sanchez, Ivan. INSTITUTO POLITÉCNICO NACIONAL (IPN);Fil: Rossomando, Francisco Guido. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Automática. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; ArgentinaFil: Pérez Alcocer, Ricardo. INSTITUTO POLITÉCNICO NACIONAL (IPN);Fil: Soria, Carlos Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Automática. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; ArgentinaFil: Carelli, Ricardo. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; ArgentinaFil: Moreno Valenzuela, Javier. INSTITUTO POLITÉCNICO NACIONAL (IPN)

Quantifying the speech-gesture relation with massive multimodal datasets: informativity in time expressions

The development of large-scale corpora has led to a quantum leap in our understanding of speech in recent years. By contrast, the analysis of massive datasets has so far had a lim- ited impact on the study of gesture and other visual communicative behaviors. We utilized the UCLA-Red Hen Lab multi-billion-word repository of video recordings, all of them showing communicative behavior that was not elicited in a lab, to quantify speech-gesture co-occur- rence frequency for a subset of linguistic expressions in American English. First, we objec- tively establish a systematic relationship in the high degree of co-occurrence between gesture and speech in our subset of expressions, which consists of temporal phrases. Sec- ond, we show that there is a systematic alignment between the informativity of co-speech gestures and that of the verbal expressions with which they co-occur. By exposing deep, systematic relations between the modalities of gesture and speech, our results pave the way for the data-driven integration of multimodal behavior into our understanding of human communication

Desarrollo de sistemas modulares robóticos y neuroprotésicos personalizables para la asistencia de la marcha patológica a través del diseño centrado en el usuario: Proyecto TAILOR

Currently available wereable exoskeletons and neuroprosthetic gait assistive devices have controverted efficacy and low penetration into rehabilitation centers because they are generic solutions that do not consider the individual requirements and characteristics of each patient. TAILOR project proposes a new approach to the design of customizable neurorobotic systems, based on robotic exoskeletons (WR) and modular neuroprosthetics (NP) to provide subject-specific solutions. These two technologies are integrated with a closed loop hybrid controller. We are using a User-Centered Design approach for the design and development of these technologies to effectively introduce the requirements and needs of patients and clinical staff. Currently, we are making modifications to the WR to integrate it to the NP, which has already been developedPeer ReviewedObjectius de Desenvolupament Sostenible::3 - Salut i BenestarPostprint (author's final draft

Futuro de los recursos hídricos en la cuenca del río Guadalfeo bajo supuesto de cambio climático

La gestión integral del agua en las cuencas mediterráneas resulta muy compleja por dos motivos fundamentales: 1) las precipitaciones son bastante escasas y su distribución espacial y temporal es muy irregular. Se alternan periodos prolongados de sequía con años de precipitaciones moderadas siendo frecuentes los episodios puntuales torrenciales; 2) el desarrollo socioeconómico está dominado por actividades que requieren importantes cantidades de agua en las épocas del año donde no se producen precipitaciones. Esta situación está previsto que se agrave con el paso de los años, cuando el cambio climático que se pronostica para estas regiones se haga efectivo. En este artículo se utiliza el modelo matemático WiM-Med para evaluar los cambios que se producirían en los distintos almacenamientos y flujos de agua de la cuenca del río Guadalfeo suponiendo que la temperatura suba 2ºC y la precipitación se reduzca en un 15% tal y como propone la Agencia Europea del Medio Ambiente. La precipitación de nieve disminuye considerablemente modificando el régimen de caudales durante la primavera. Esto supondrá tener que buscar nuevas medidas de gestión o nuevos usos del territorio que impliquen menores consumos de agua, de tal forma que se encuentre un consenso entre demandas y recursos.Water management in semiarid basins flowing into the Mediterranean Sea is rather complex because: 1)rainfall is scarce in these regions and it is irregularly distributed in space and time and 2) the socio-economic development of these regions is based on activities demanding high amounts of water (tourism, intensive agriculture, etc.) that would not be available during the summer time without management. This situation could be critical if the present predictions of climate change become true. In this work we use the mathematical model WiM-Med to simulate the different changes taking place in the water flows and reservoirs of the Guadalfeo river basin assuming that the temperature increases 2-3 ºC and rainfall decreases 15%. Results show that the snow decreases considerably, which causes a notable modification of the river flow during spring. Therefore, in the future, new management techniques should be applied or it would be necessary to adapt the land uses, reaching an agreement between the water demand and the resources.Grupo de Dinámica de Flujos Ambientales. Centro Andaluz de Medio Ambiente. Grupo de Hidrología e Hidráulica Agrícola. Universidad de Córdoba

Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model

Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic neurites, contributing to synaptic impairment. In addition to phospho-tau, AD brains accumulate amyloid-beta. This study evaluated the effect of the brain-penetrant microtubule-stabilizing agent, Epothilone D (EpoD) in the progression of the disease in a double transgenic mouse model of amyloidosis. Young APP/PS1 mice were weekly treated with intraperitoneal injections of EpoD (2 mg/kg) or vehicle solution for 3 months. Memory performance was tested using object-recognition tasks, Y-maze and Morris water maze. EpoD-treated mice improved their performance of cognitive tests, while hippocampal phospho-tau and Aβ levels, especially soluble oligomers, decreased significantly. β/γ-secretase activities were not affected by EpoD in vitro. A significant amelioration of synaptic/neuritic pathology was found. Remarkably, EpoD exerted a neuroprotective effect on SOM-interneurons, a highly AD-vulnerable GABAergic subpopulation. In conclusion, EpoD improved microtubule dynamics and axonal transport in an AD-like context, reducing tau and Abeta accumulation, and promoting neuronal and cognitive protection. These results underline the crosstalk between cytoskeleton pathology and proteinopathy. Therefore, microtubule-stabilizing drugs could be candidates for slowing AD progression at both tau and Aβ pathologies.Supported by PI18/01557 (to AG) and PI18/01556 (to JV) grants from ISCiii of Spain, co-financed by FEDER funds from European Union, CIBERNED collaborative grant (to AG and JV), and by PPIT.UMA.B1.2017/26 grant (to RSV). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech